Systemic mastocytosis associated with chronic myelomonocytic leukemia and xanthogranuloma
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چکیده
منابع مشابه
Systemic mastocytosis associated with chronic myelomonocytic leukemia and xanthogranuloma
A patient with a history of non-diagnostic bone marrow biopsies presented with a red to brown maculopapular rash on the back. Biopsies confirmed multiple xanthogranulomas as well as a mastocytosis. A consequently performed bone marrow biopsy verified a systemic mastocytosis and a chronic myelomonocytic leukemia (CMML) type I. HERE, WE DESCRIBE FOR THE FIRST TIME IN THE LITERATURE A PATIENT WITH...
متن کاملSystemic mastocytosis with associated acute myelogenous leukemia.
Systemic mastocytosis (SM) is a condition associated with a clonal neoplastic proliferation of mast cells. Approximately 40% of patients with SM present with an associated clonal hematological non-mast cell lineage disorder. Patients presenting with SM-acute myeloid leukemia (AML) have the worst prognosis. We present a case of a 62-year-old woman who was diagnosed with SM-AML. After initial tre...
متن کاملNovel recurrent mutations in ethanolamine kinase 1 (ETNK1) gene in systemic mastocytosis with eosinophilia and chronic myelomonocytic leukemia
Although KITD816V occurs universally in adult systemic mastocytosis (SM), the clinical heterogeneity of SM suggests presence of additional phenotype-patterning mutations. Because up to 25% of SM patients have KITD816V-positive eosinophilia, we undertook whole-exome sequencing in a patient with aggressive SM with eosinophilia to identify novel genetic alterations. We conducted sequencing of puri...
متن کاملModelling of a genetically diverse evolution of Systemic Mastocytosis with Chronic Myelomonocytic Leukemia (SM-CMML) by Next Generation Sequencing
BACKGROUND Systemic mastocytosis (SM) is a heterogenous, clonal mast cell (MC) proliferation, rarely associated with clonal hematologic non-mast cell lineage disease (SM-AHNMD). KIT (D816V) is regarded as driver-mutation in SM-AHNMD. METHODS DNA isolated from peripheral blood (PB) of an SM-CMML patient was investigated with targeted next generation sequencing. Variants were verified by Sanger...
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NR: Not reported, FCR: fludarabine, cyclophosphamide, rituximab; MUD AHSCT: matched unrelated donor allogeneic hematopoietic stem cell transplantation, CR: complete remission, CLL: chronic lymphocytic leukemia, SM: systemic mastocytosis. Systemic Mastocytosis with Associated Chronic Lymphocytic Leukemia: A Matter of Diseases or Prognostic Factors? Kronik Lenfositik Lösemi ile Birlikte Seyreden ...
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ژورنال
عنوان ژورنال: Dermatology Practical & Conceptual
سال: 2012
ISSN: 2160-9381
DOI: 10.5826/dpc.0203a03